Téléchargez le livre : Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells

Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells

Mathematical Modeling and Experimental Observations
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Éditeur :

Springer

Collection : Springer Theses

Paru le : 2015-02-16

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheosta...
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Description du livre

This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.

À propos

Auteur
Iman Tavassoly
Éditeur
Springer
Collection
Springer Theses
Parution
2015-02-16
Pages
79 pages
EAN papier
9783319149615

Auteur(s) du livre


Defaut-Illustration Iman Tavassoly

Caractéristiques détaillées - droits

EAN EPUB
9783319149622
Prix
94,94 €
Nombre pages copiables
0
Nombre pages imprimables
7
Taille du fichier
1546 Ko
Ce livre est accessible aux handicaps informations d'accessibilité

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